Given that each side plays each other twice (home and away), every team in the Premier League plays a total of 38 league fixtures in a single season, 19 at home and 19 away from home.
The record for the biggest win in Premier League history is shared by Liverpool, Manchester United, and Leicester City, who have all won a match in the competition by a scoreline of 9-0. United have done it twice. The Red Devils achieved that feat first when they thrashed Ipswich Town back in March 1995.
